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目的对６例诊断为多灶性运动神经病（ＭＭＮ）的病例进行研究，并就一些相关问题进行讨论。方法采用ＣｏｕｎｔｅｒｐｏｉｎｔＭＫⅡ肌电图仪进行电生理研究，ＥＬＩＳＡ法测血及脑脊液中抗神经节苷脂ＧＭ１抗体，５例病人行腓肠神经活检。结果６例病人中５例为上肢起病，上肢受累为主，远端重。５例有感觉症状，但仅２例查体有轻度感觉缺失。均表现为无力、肌萎缩和腱反射减弱或消失。所有病人都有运动传导阻滞。４例病人血抗ＧＭ１抗体滴度升高。病理示脱鞘及髓鞘再生。结论结果表明ＭＭＮ为一高度特异的脱鞘性周围神经病，电生理以运动传导阻滞为特点。多数病人对免疫治疗有效。此研究与国外报道一致，但尚需进一步的研究
Objective To study 6 cases diagnosed as multifocal motor neuropathy (MMN) and to discuss some related issues. Methods Electrophysiological study was performed with Counterpoint MK Ⅱ electromyograph. Serum and anti-ganglioside GM1 antibodies in cerebrospinal fluid (CSF) were detected by ELISA and sural nerve biopsies were performed in 5 patients. Results Among the 6 patients, 5 were mainly upper extremities, upper extremities were involved, and distal ones were heavier. Five patients had sensory symptoms, but only two patients had mild sensory loss. Both showed weakness, muscle atrophy and tendon reflexes diminished or disappeared. All patients had motor block. 4 cases of patients with anti-GM1 antibody titers increased. Pathological demyelination and remyelination. Conclusion The results show that MMN is a highly specific demyelinating peripheral neuropathy and electrophysiology is characterized by motor block. Most patients are effective on immunotherapy. This study is consistent with foreign reports, but further research is needed