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用卵蛋白吸入诱导豚鼠哮喘动物模型（哮喘组），然后，进行支气管肺泡灌洗，分析支气管肺泡灌洗细胞学改变。哮喘组支气管肺泡灌洗液中的细胞总数、嗜酸性粒细胞绝对计数及低密度嗜酸性粒细胞比例均显著高于正常对照组（Ｐ＜０．０５、Ｐ＜０．０１）。哮喘动物模型在吸入抗原激发之前，用血小板活化因子特异性拮抗剂银杏苦内酯（ＢＮ５２０２１）预处理后，支气管肺泡灌洗液中细胞总数、分类和嗜酸性粒细胞数量均与哮喘组差异无显著性。但低密度嗜酸性粒细胞比例却显著降低（Ｐ＜０．０５）。用地塞米松预处理动物模型（激素组）后，支气管肺泡灌洗液中的细胞总数、嗜酸性粒细胞数、细胞分类及低密度嗜酸性粒细胞比例均降至正常对照组水平。结果表明：银杏苦内酯能显著减少哮喘动物气道内“活化”状态的低密度嗜酸性粒细胞，可能是一种有用的哮喘抗炎药物。
The guinea pig asthma animal model was induced by ovalbumin inhalation (asthma group), followed by bronchoalveolar lavage to analyze the cytology changes of bronchoalveolar lavage. The total number of cells, absolute eosinophil count and low density eosinophils in bronchoalveolar lavage fluid in asthma group were significantly higher than those in normal control group (P <0.05, P <0.01). Animal models of asthma Before bronchoalveolar lavage fluid pretreatment with progesterone-specific antagonist ginkgolide (BN52021), the total number of cells in the bronchoalveolar lavage fluid and the number of eosinophils in bronchoalveolar lavage fluid were different from those in the asthma group Significance. However, the proportion of low density eosinophils was significantly lower (P <0.05). After pretreatment with dexamethasone, the total number of cells, eosinophils, cell sorting and low-density eosinophils in bronchoalveolar lavage fluid were all reduced to normal levels in the animal model (hormone group). The results showed that ginkgolide could significantly reduce low density eosinophils in the “activated” state of asthmatic animals’ airways, which may be a useful asthma anti-inflammatory drug.