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目的:采用超声评价经冠状动脉自体骨髓干细胞移植治疗后高海拔地区急性心肌梗塞左室收缩功能及心肌局部运动改变。方法:2004年3月—2007年6月期间入院的33例急性前壁心肌梗死患者随机分为两组,细胞移植组患者在术前、术后6月、术后12月行超声检查,测量左室射血分数(LVEF)、左室舒张末期容积(EDV)、左室收缩容积(ESV)、每搏量(SV)。结果:移植术后6月患者左室射血分数由术前(40.93±7.38)%升至(48.57±5.17)%,(P<0.05)。结论:自体骨髓干细胞移植可明显改善左心室收缩功能和心肌局部运动。
OBJECTIVE: To evaluate the changes of left ventricular systolic function and myocardial local motion in patients with acute myocardial infarction at high altitude after transcatheter arterial bone marrow stem cell transplantation using ultrasound. Methods: Thirty-three patients with acute anterior myocardial infarction admitted to our hospital from March 2004 to June 2007 were randomly divided into two groups. The patients in the cell transplantation group underwent ultrasound examination before operation, 6 months after operation and 12 months after operation. Left ventricular ejection fraction (LVEF), left ventricular end-diastolic volume (EDV), left ventricular systolic volume (ESV) and stroke volume (SV). Results: The left ventricular ejection fraction increased from (40.93 ± 7.38)% to (48.57 ± 5.17)% at 6 months after transplantation (P <0.05). Conclusion: Autologous bone marrow stem cell transplantation can significantly improve left ventricular systolic function and myocardial local motion.