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目的探讨卵巢非特异性类固醇细胞瘤的临床病理特点。方法对1例卵巢非特异性类固醇细胞瘤进行HE染色、光镜观察、免疫组化及特殊染色,并结合临床资料进行文献复习。结果肿瘤组织学形态显示,瘤细胞呈圆形或多边形,细胞胞质较宽,嗜酸性颗粒状或透明空泡状,肿瘤内薄壁窦状血管较为丰富。免疫组化:瘤细胞特征性α-inhibin、calretinin、CK-pan和CD99(+)。特殊染色显示苏丹Ⅲ(+),PAS(-)。结论卵巢非特异性类固醇细胞瘤是一种极少见的肿瘤,组织病理学特点结合免疫组化标记有助于该瘤的确诊。
Objective To investigate the clinicopathological features of ovarian nonspecific steroid tumor. Methods One case of ovarian nonspecific steroid cell tumor was examined by HE staining, light microscopy, immunohistochemistry and special staining combined with clinical data. Results Tumor histology showed that the tumor cells were round or polygonal with wide cytoplasm, eosinophilic granules or clear vacuoles, and the thin-walled sinusoids in the tumor were abundant. Immunohistochemistry: tumor cells characteristic α-inhibin, calretinin, CK-pan and CD99 (+). Special staining showed Sudan Ⅲ (+), PAS (-). Conclusions Ovarian nonspecific steroid cell tumor is an extremely rare tumor. The combination of histopathological features and immunohistochemical staining is helpful for the diagnosis of this tumor.