论文部分内容阅读
目的观察2种浓香型白酒对大鼠血脂及脂代谢关键酶的影响,分析不同酒样对脂代谢影响的差异,探讨适量饮酒调节机体脂代谢的可能机制。方法 105只雄性SD大鼠随机分为7组,分别为1-1、1-2、1-3、2-1、2-2、2-3和对照组,按低、中、高剂量分别灌服2种浓香型白酒,连续灌胃8周,检测大鼠肝功、血脂及脂肪分解、合成关键酶水平,对比组间差异。结果 AST水平1-3、2-1、2-2组较对照组有降低(P<0.05);与对照组相比,1-2组ATGL升高(P<0.05),且酒样1的3个剂量组分别高于酒样2的3个剂量组(P<0.05);2-1、2-3组HSL升高(P<0.05),且2-1组高于1-1组(P<0.05);酒样2的3个剂量组CPT-I水平均降低(P<0.05),1-1、1-2组分别高于2-1、2-2组;酒样组的ACO水平和DCAT水平较对照组分别升高(P<0.05)和降低(P<0.05);2-2组FAS水平低于对照组(P<0.05)。结论适量浓香型白酒可提高部分脂肪分解关键酶水平,同时降低脂肪合成关键酶水平,这可能是适量饮酒对机体脂代谢调节的机制之一,这种调节作用可能与饮酒品质相关。
Objective To observe the effects of two kinds of Luzhou-flavor liquor on the key enzymes of blood lipids and lipid metabolism in rats and analyze the differences of lipid metabolism in different alcoholic drinks to explore the possible mechanism of moderate alcohol intake regulating lipid metabolism. Methods 105 male Sprague-Dawley rats were randomly divided into 7 groups: 1-1, 1-2, 1-3, 2-1, 2-2, 2-3 and control group, respectively. Two kinds of Luzhou-flavor white spirits were drenched and continuously fed for 8 weeks. The levels of liver enzymes, lipids and lipolysis in rats were determined, and the key enzymes were synthesized. The differences between the two groups were compared. Results Compared with the control group, the levels of AST in 1-2 groups were significantly increased (P <0.05), and the levels of AST in 1-3, 2-1, 2-2 groups were lower than those in control group (P <0.05). The levels of HSL in 2-1 and 2-3 group were significantly higher than those in the other two groups (P <0.05), and those in 2-1 group were higher than those in 1-1 group P <0.05). The levels of CPT-I in the three doses of wine sample 2 were decreased (P <0.05), and those in 1-1 and 1-2 groups were higher than those in 2-1 and 2-2 groups (P <0.05) and decreased (P <0.05) respectively. The level of FAS in 2-2 group was lower than that in control group (P <0.05). Conclusions A proper amount of Luzhou-flavor liquor can increase the level of some enzymes involved in lipolysis and decrease the level of key enzymes in lipolysis, which may be one of the mechanisms that regulate the lipid metabolism in moderate body fluids. This regulative effect may be related to the quality of drinking.