资料表明,酮体酚能抑制组织胺,慢反应物质和其它活性介质,自肥大细胞和粒细胞中释放出,对过敏性鼻炎具有良好的治疗作用。但是口服有明显嗜睡的副作用。为此,我们设计了以酮体芬为主药的鼻腔膜剂。并进行了临床观察及酮体酚含量测定方法的观察。①制备:取酮体酚0.03、麻黄素0.3,地塞米松0.003分别溶于水,再与作为膜剂基质的PVA、CMC—Na液混和,加入甘油混匀,除泡涂膜,干燥分格起 The data show that keto-phenol can inhibit histamine, slow reaction substances and other active mediators, released from mast cells and granulocytes, and has a good therapeutic effect on allergic rhinitis. However, there are obvious side effects of somnolence. To this end, we designed a nasal cavity film based on ketoprofen. Clinical observations and ketophenol content determination methods were observed. 1 Preparation: Ketone phenol 0.03, ephedrine 0.3, and dexamethasone 0.003 were respectively dissolved in water, mixed with PVA, CMC-Na solution as the matrix of the film, and mixed with glycerin to remove bubbles and dry the cells. From