论文部分内容阅读
探讨胃癌病人血清ＴＮＦ－α和ＩＬ－６水平的变化及其临床意义。方法：利用ＥＬＩＳＡ法测定３５例胃癌病人血清ＴＮＦ－α和ＩＬ－６水平，并与胃良性肿瘤组和正常对照组相比较。结果：胃癌病人血清ＴＮＦ－α和ＩＬ－６水平明显增高（Ｐ＜０．０１），并与疾病分期有关（Ｐ＜０．０５），病灶切除后血清ＴＮＦ－α和ＩＬ－６水平明显降低（Ｐ＜０．０５）。结论：胃癌病人具有细胞免疫功能紊乱，血清中ＴＮＦ－α和ＩＬ－６水平的增高可能和疾病的发生发展有关，测定血清ＴＮＦ－α和ＩＬ－６可作为胃癌病人病情判断和疗效观察的指标之一。
To investigate the changes and clinical significance of serum TNF-α and IL-6 levels in patients with gastric cancer. Methods: Serum TNF-α and IL-6 levels in 35 patients with gastric cancer were measured by ELISA and compared with benign gastric tumors and normal controls. Results: Serum TNF-α and IL-6 levels were significantly higher in gastric cancer patients (P<0.01) and related to disease stage (P<0.05). Serum TNF-α and IL-6 levels were significantly reduced after resection of gastric cancer. (P<0.05). Conclusion: The patients with gastric cancer have disordered cellular immune function. The increase of TNF-α and IL-6 levels in serum may be related to the development of the disease. Determination of serum TNF-α and IL-6 levels may be used as an indicator to judge the condition of patients with gastric cancer and observe the curative effect. one.