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目的探讨降钙素原和超敏C反应蛋白对早期新生儿感染性疾病诊断的价值。方法选择本院新生儿科病房2013年8月-2014年6月共计120例患感染性疾病的新生儿为研究对象,定义为感染组。对照组为来本院分娩的120例健康新生儿。入院后对所有研究对象血浆采集降钙素原和超敏C反应蛋白。比较感染组及对照组的降钙素原、超敏C反应蛋白检测结果以及感染组降钙素原、超敏C反应蛋白阳性率。结果感染组及对照组的降钙素原、超敏C反应蛋白检测结果分别为11.5μg/L±2.6μg/L、12.7 mg/L±3.1 mg/L和0.3μg/L±0.1μg/L、4.2 mg/L±1.2 mg/L,差异有统计学意义(P<0.05);感染组PCT、hs-CRP检测阳性率、敏感性、特异性差异有统计学意义(P<0.05)。结论本院认为新生儿在感染急性期,降钙素原、超敏C反应蛋白均能明显增高,但是对于诊断早期新生儿感染性疾病,降钙素原阳性率比超敏C反应蛋白高。
Objective To investigate the value of procalcitonin and high sensitivity C-reactive protein in the diagnosis of early neonatal infectious diseases. Methods A total of 120 newborns with infectious diseases were selected from the Department of Neonatology Ward from August 2013 to June 2014. The patients were defined as infection group. The control group came to our hospital for delivery of 120 healthy newborns. Plasma procalcitonin and hypersensitive C-reactive protein were collected from all subjects after admission. The levels of procalcitonin, hypersensitive C-reactive protein and the positive rates of procalcitonin and hs-CRP in infected and control groups were compared. Results The results of detection of procalcitonin and hs-CRP in infected group and control group were 11.5μg / L ± 2.6μg / L, 12.7mg / L ± 3.1mg / L and 0.3μg / L ± 0.1μg / L respectively , 4.2 mg / L ± 1.2 mg / L, the difference was statistically significant (P <0.05). The positive rates of PCT and hs-CRP in the infected group were statistically significant (P <0.05). Conclusions Our hospital believes that neonates with acute infection, procalcitonin, high-sensitivity C-reactive protein can be significantly increased, but for the diagnosis of early neonatal infectious diseases, procalcitonin positive rate higher than the high-sensitivity C-reactive protein.