Statins are one of the most popular lipid-lowering drugs( LLDs). Upon oral administration,these drugs are well absorbed by the intestine and effectively used for the treatment of dyslipidemias. This manuscript aims to investigate the demographics of the data who used Statins,review the benefits and challenges of Statins and the future of the treatment. Upon oral administration, these drugs are well absorbed by the intestine and effectively used for the treatment of dyslipidemias. This manuscript aims to investigate the demographics of the data who used statins, review the benefits and challenges of Statins and the future of the treatment.