论文部分内容阅读
目的:探讨比较GnRH激动剂(GnRH-a)长效剂型和短效剂型在长方案中的临床应用效果。方法:将IVF-ET/ICSI治疗的长方案患者按照GnRH-a的不同剂型分为长效组(A组)和短效组(B组),比较A、B组间垂体降调节效果、促排卵过程及妊娠结局。结果:A组促性腺激素(Gn)总量、Gn使用天数、hCG注射日P、P/E2、子宫内膜厚度、平均获卵数、受精率及中、重度卵巢过度刺激综合征(OHSS)发生率高于B组,差异有统计学意义(P<0.05);B组hCG注射日LH、E2、OHSS取消率、优质胚胎率、流产率较A组高,差异有统计学意义(P<0.05)。移植胚胎数、移植妊娠率、着床率、宫外妊娠率比较组间无显著差异。结论:在控制性超促排卵(COH)长方案中应用GnRH-a长、短效2种剂型均可获得较满意的垂体降调节效果,虽各有利弊,但并不影响妊娠结局。
Objective: To investigate the clinical efficacy of long-acting and short-acting GnRH-a agonists (GnRH-a) in long-term regimens. Methods: Long-term patients treated with IVF-ET / ICSI were divided into long-acting group (A group) and short-acting group (B group) according to the different dosage forms of GnRH-a. Ovulation and pregnancy outcomes. Results: The total amount of gonadotropin (Gn), days of Gn, P, P / E2, endometrial thickness, mean number of oocytes retrieved, fertilization rate and moderate and severe ovarian hyperstimulation syndrome (OHSS) (P <0.05). The abolishment rates of LH, E2 and OHSS on the day of injection on the day of hCG in group B were higher than those in group A, the difference was statistically significant (P < 0.05). Transplanted embryos, pregnancy rate, implantation rate, ectopic pregnancy rate was no significant difference between groups. Conclusions: The long-term and short-term effects of GnRH-a in long-term controlled ovarian hyperstimulation (COH) regimen can achieve more satisfactory pituitary down-regulation effect, which has advantages and disadvantages, but does not affect pregnancy outcome.