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目的:原发性高血压病(Essential hypertension,EH)是人类心血管疾病发病率最高的一种疾病。迄今为止,其发病机制仍然不十分清楚,但是大量的研究表明,EH是多个基因和环境因素共同影响所致的复杂遗传性状疾病[1-2],在众多的EH候选基因和候选位点中,编码肾素-血管紧张素的基因是最有可能的易感基因,其中血管紧张素原(AGT)作为血管紧张素Ⅱ(AngⅡ)的前体物质,其浓度变化限制RAS中AngⅡ的转化速度。目前有关AGT基因多态性与EH之间关系的结论不尽相同,本文将对二者的相关性研究进展作一综述。
PURPOSE: Essential hypertension (EH) is the most prevalent form of human cardiovascular disease. So far, its pathogenesis is still not very clear, but a large number of studies have shown that EH is a complex genetic trait caused by a combination of genetic and environmental factors [1-2]. In many EH candidate genes and candidate sites , The gene encoding renin-angiotensin is the most likely susceptible gene, of which angiotensinogen (AGT) acts as a precursor of angiotensin II (Ang II), and its concentration change limits the conversion of Ang II in RAS speed. At present, the conclusions about the relationship between AGT gene polymorphism and EH are not the same. This article reviews the research progress of the correlation between AGT gene and EH.