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为了增加强化疗的安全性,15例次初治及32例次巩固强化治疗的急性髓性白血病患儿化疗中应用粒细胞集落刺激因子,中性粒细胞绝对值小于0.5×10~9/L的持续时间分别为5.3天、5.0天,与化疗方案相同的对照组相比分别缩短了5.6天、3.6天;感染发生率为40％、25％,较对照组下降了26.7％,19.4％,具显著差异(P<0.05);输血量亦随之减少,副作用少,提高了病人的生活质量,为强化疗治疗小儿急性髓性白血病提供了保障。
In order to increase the safety of intensive chemotherapy, 15 cases of primary treatment and 32 cases of sub-consolidated intensive treatment of children with acute myeloid leukemia in the application of granulocyte colony stimulating factor, neutrophils absolute value of less than 0.5 × 10 ~ 9 / L Were 5.6 days and 3.6 days shorter than the control group with the same chemotherapy regimen. The incidence of infection was 40% and 25%, which was 26.7% and 19.4% lower than that of the control group, (P <0.05). The amount of blood transfusion decreased with fewer side effects, which improved the quality of life of patients and provided a guarantee for intensive chemotherapy in the treatment of children with acute myeloid leukemia.