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目的 观察国产甲型肝炎减毒活疫苗 (H2 株 )在甲型肝炎流行情况下 ,其保护发病与保护感染效果。方法 在某乡甲肝流行情况下 ,采用病例对照研究方法 ,调查病例组与对照组甲肝疫苗免疫史 ,估计疫苗保护发病效果 ;选择该乡发病率较高的 13个村小学学生 ,进行血清学及甲肝疫苗接种史调查 ,计算疫苗保护感染效果。结果 甲肝减毒活疫苗保护率为98 1%,95 %可信限下限为 83 5 %。隐性感染率在接种组与未接种组分别为 10 2 3%和 11 5 9%,两者无统计学差异。结论 国产甲型肝炎减毒活疫苗 (H2 株 )具有很好的保护发病效果 ,可以同国外灭活疫苗相媲美 ,其保护感染效果不及保护发病效果。
Objective To observe the effectiveness of live attenuated hepatitis A vaccine (H2 strain) in the pathogenesis of hepatitis A and the protection of infection. Methods A case-control study was conducted to investigate the immunization history of hepatitis A vaccine in case group and control group in order to estimate the effect of vaccine protection. A total of 13 village primary school students with high prevalence in this village were selected for serological and Hepatitis A vaccination history survey to calculate the vaccine to protect the infection. Results The live attenuated hepatitis A vaccine coverage was 98.1% with a 95% lower confidence limit of 83.5%. The prevalence of latent infection was 102.3% and 11.59% respectively in the vaccinated and non-vaccinated groups, with no significant difference between the two groups. Conclusion The attenuated live attenuated hepatitis A vaccine (H2 strain) has a good effect of protection against inactivation and comparable to that of inactivated vaccine abroad, which can not protect against the infection.