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目的探讨高敏C反应蛋白(hs-CRP)和心肌损伤标志物等在冠心病发生、发展过程中的作用,以及与疾病严重程度的关系。方法选择2009年至2011年收治的冠心病患者96例,其中稳定型心绞痛患者(SAP组)30例,不稳定型心绞痛患者(UAP组)33例,急性心肌梗死患者(AMI组)33例,另选择门诊同期健康体检者40例作为对照组。收集所有受试者5ml静脉血,分离血清,分别测定hs-CRP和心肌损伤标志物水平。结果 hs-CRP和肌钙蛋白T(cTn-T)水平4组存在统计学差异,其中AMI组>UAP组>SAP组>对照组(P<0.01);肌酸激酶同工酶(CK-MB)水平仅AMI组显著高于其他3组(P<0.01),其他3组互相间差异无统计学意义(P>0.05)。结论 hs-CRP、cTn-T和CK-MB联合检测互相补充,对冠心病的诊断具有重要的临床诊断和预后判断的意义。
Objective To investigate the role of high-sensitivity C-reactive protein (hs-CRP) and myocardial injury markers in the development and progression of coronary heart disease (CHD) and its relationship with the severity of the disease. Methods Ninety-six patients with coronary heart disease were selected from 2009 to 2011. Thirty patients with stable angina pectoris (SAP group), 33 patients with unstable angina pectoris (UAP group), 33 patients with acute myocardial infarction (AMI group) Another choice of outpatient health examination during the same period 40 cases as a control group. All subjects were collected 5ml venous blood, serum was isolated, were measured hs-CRP and myocardial injury marker levels. Results The levels of hs-CRP and troponin T (cTn-T) in four groups showed statistical difference, among which AMI group> UAP group> SAP group> control group (P <0.01) ) Levels were significantly higher in the AMI group than those in the other three groups (P <0.01). There was no significant difference between the other three groups (P> 0.05). Conclusion The combined detection of hs-CRP, cTn-T and CK-MB complement each other and has important clinical diagnosis and prognostic significance in the diagnosis of coronary heart disease.