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首创巴豆油和正丁酸联合诱导Ｒａｊｉ细胞获得ＥＢＶ－ＤＮａｓｅ，确定了其产生的时态曲线。建立了检测ＮＰＣ病人ＤＮａｓｅ抗体的方法，首次采用“抗酶率”表示抗体水平，并根据其滴度分布曲线确定了抗酶率大于３０％为阳性截止值，经双盲法检测、普查及５万余例ＮＰＣ门诊病人标本的检测，证明抗酶率检测结果稳定可靠，对发现早期ＮＰＣ有重要作用。首次用ＰＣＲ扩增出ＤＮａｓｅ全基因，并高效表达成功；重组的ＤＮａｓｅ有较高的活性和良好抗原性，可用于临床检测。首创用ＰＣＲ扩增组织中ＤＮａｓｅ和核抗原１基因来发现早期ＮＰＣ或用于其相关疾病鉴别诊断；并用ＰＣＲ扩增石蜡包埋组织中该两种基因片段来进行回顾性病因研究。
The first Croton oil and n-butyric acid induced Raji cells to obtain EBV-DNase, to determine the tense curve. The method of detecting DNase antibody in NPC patients was established. The antibody level was indicated by “anti-enzyme rate” for the first time. According to its titer distribution curve, the anti-enzyme rate was higher than 30%, which was positive cut-off value. More than 10,000 cases of NPC outpatient specimens tested, anti-enzyme test results proved stable and reliable, early detection of NPC have an important role. The first full-length DNase gene was amplified by PCR and expressed successfully. Recombinant DNase has high activity and good antigenicity and can be used for clinical testing. The first use of PCR amplification of DNase and nuclear antigen 1 tissue to detect early NPC or for the differential diagnosis of their associated diseases; and PCR amplification of these two gene fragments in paraffin-embedded tissue for retrospective etiological studies.