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目的阐明血管紧张素转化酶（ACE）基因多态性及循环中ACE水平不同在肾脏疾病进展中的意义。方法对50名终末期肾功能衰竭（ESRF）患者和60名正常人ACE基因多态性进行分析。结果ACE基因在ESRF组和正常人组杂合子型（DI）和缺失型（DD）明显高于正常人，而插入型（Ⅱ）的发生率ESRF明显低于正常人。结论ACE基因多态性与肾衰的发展及肾小球硬化的发生有一定联系，ACE基因多态性的分析，可望成为判断肾脏疾病患者预后的一个新的筛查指标。
Objective To elucidate the significance of angiotensin converting enzyme (ACE) gene polymorphism and different circulating ACE levels in the progression of renal disease. Methods ACE gene polymorphisms in 50 patients with end-stage renal failure (ESRF) and 60 normal controls were analyzed. Results The ACE gene levels in ESRF group and normal group were significantly higher than those in normal subjects (DI) and normal controls (DD). The incidence of inserted type Ⅱ (Ⅱ) was significantly lower than that in normal subjects. Conclusion The ACE gene polymorphism is associated with the development of renal failure and the occurrence of glomerulosclerosis. The analysis of ACE gene polymorphism may be a new screening index for judging the prognosis of patients with renal disease.