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目的：了解内毒素血症时各脏器受损的病理组织学变化及东莨菪碱和前列腺素Ｅ１的保护作用。方法：大耳白兔５０只，随机分为５组：Ａ组为对照组；Ｂ组为内毒素致伤组（７００μｇ／ｋｇ）；Ｃ组、Ｄ组分别为内毒素致伤后东莨菪碱和前列腺素Ｅ１治疗组，Ｅ组为东莨菪碱和前列腺素Ｅ１联合治疗组。实验前及实验后０．５、２、４和６小时分别测血压和呼吸频率；实验后６．５小时放血处死动物，测肺毛细血管通透指数，同时取肺、心、脑、肝、肾、肾上腺和脾组织作光镜及电镜检查。结果：Ｂ组动物全部于实验后０．５小时出现休克和呼吸困难；６．５小时测得的肺毛细血管通透指数显著高于对照组，各脏器的病理组织学改变以肺最为明显且严重。各治疗组肺受损均轻于Ｂ组，其它脏器在实验后６．５小时的病理变化不明显。结论：内毒素休克时，肺是敏感且最早受损的脏器；东莨菪碱和前列腺素Ｅ１联合治疗组的疗效基本与两药单独治疗组相同。
OBJECTIVE: To understand the histopathological changes of impaired organ in endotoxemia and the protective effect of scopolamine and prostaglandin E1. Methods: 50 rabbits were randomly divided into 5 groups: group A was control group; group B was endotoxin-injured group (700μg / kg); group C and group D were scopolamine-induced endotoxin and prostate E1 treatment group, E group scopolamine and prostaglandin E1 combined treatment group. Blood pressure and respiration rate were measured at 0.5, 2, 4 and 6 hours before and after the experiment. Animals were sacrificed at the end of 6.5 hours after the experiment. Pulmonary capillary permeability index was measured. Lung, heart, brain, liver, Kidney, adrenal and spleen tissue for light and electron microscopy. Results: All rats in group B developed shock and dyspnea 0.5 hours after the experiment. The pulmonary capillary permeability index measured at 6.5 hours was significantly higher than that of the control group, and the pathological changes of the organs were the most obvious in the lung And serious. Lung damage in each treatment group were lighter than in group B, other organs in the experimental 6.5 hours after the pathological changes were not obvious. Conclusions: LPS is the most sensitive and earliest organ in endotoxic shock. The combination of scopolamine and prostaglandin E1 is the same as the two drugs alone.