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化学和生物因子持续或反复损伤肝组织时,肝脏发生炎症细胞浸润和肝细胞坏死。机体的抗损伤反应除有肝细胞再生外,尚有大量的纤维组织增生。每 g 新鲜的正常肝组织约含5.5mg 胶原,肝纤维化时其含量增加2～6倍。过度的纤维化和纤维结节形成是肝硬化临床表现和并发症的病理基础,减少肝内胶原的合成和增加它的降解理论上可使慢性肝病得到缓解。
Chemical and biological factors sustained or repeated damage to liver tissue, the liver inflammatory cell infiltration and liver cell necrosis. The body’s anti-injury response in addition to liver cell regeneration, there are a large number of fibrous tissue hyperplasia. Each g of fresh normal liver tissue contains about 5.5mg of collagen, liver fibrosis when its content increased by 2 to 6 times. Excessive fibrosis and nodule formation are the pathological basis for the clinical manifestations and complications of cirrhosis. Reducing intrahepatic collagen synthesis and increasing its degradation can theoretically ameliorate chronic liver disease.