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目的探讨血清胰岛素样生长因子-1(IGF-1)在胃肠道恶性肿瘤诊治中的临床价值。方法收集46例胃肠道恶性肿瘤患者(其中术前组26例,术后化疗组20例)和20例胃肠道良性病变患者血清标本(良性病变组),同时收集26例健康体检者血清作为对照(健康对照组),血清标本行IGF-1放射免疫分析检测和癌胚抗原(CEA)、糖链抗原199(CA199)化学发光检测。用ROC曲线进行检测效能分析。结果术前组IGF-1水平为(587.38±385.25)ng/ml,显著高于健康对照组(P<0.01),IGF-1水平术后化疗组与健康对照组、良性病变组差异均无统计学意义(均P>0.05)。当IGF-1阈值为231.80 ng/ml时,诊断胃肠道恶性肿瘤的灵敏度为92.30%,特异度为97.8%。结论 IGF-1在胃肠道恶性肿瘤的诊治中有一定的临床应用价值。
Objective To investigate the clinical value of serum insulin-like growth factor-1 (IGF-1) in the diagnosis and treatment of gastrointestinal cancer. Methods Totally 46 patients with gastrointestinal cancer (26 in preoperative group, 20 in postoperative chemotherapy group) and 20 serum samples in benign lesions of gastrointestinal tract (benign lesion group) were collected from 46 patients with gastrointestinal cancer. Serum Serum samples were detected by radioimmunoassay of IGF-1 and carcinoembryonic antigen (CEA), glyco-antigen 199 (CA199) as a control (healthy control group). Using ROC curve for performance analysis. Results The level of IGF-1 in the preoperative group was (587.38 ± 385.25) ng / ml, which was significantly higher than that in the healthy control group (P <0.01). No difference was found between the IGF-1 level in the chemotherapy group and the healthy control group and benign lesion group Significance (both P> 0.05). When IGF-1 threshold was 231.80 ng / ml, the sensitivity of gastrointestinal cancer diagnosis was 92.30% and the specificity was 97.8%. Conclusion IGF-1 has certain clinical value in the diagnosis and treatment of gastrointestinal malignancies.