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目的:为了探讨胃食管返流的拮抗机制。方法:对33只大白鼠进行食管测压.观测呼吸过程中胸腹内压力变化及其压力差,描记食管压力曲线图并了解其解剖结构。结果:大白鼠腹段食管相对较长,呼吸过程中腹内压力始终高于胸内压力。压力曲线图上可见食管下端括约肌压力(LESP)和隔肌脚对食管的关闭压力(DPP),前者呈平台状,为食管下段括约肌形成的高压带,后者呈波浪形,波动频率与呼吸频率一致,两者间的距离等于腹段食管长度,为膈肌收缩挤压食管所致。本组实验动物中同时存在 LESP 和 DPP 者占48.5%,仅见 LESP 或 DPP 者占18.2%和33.3%。LESP 和 DPP 的压力均值为2.32±1.133kPa(17.4±8.5mmHg)和2.24±1.04kPa(16.8±7.8mmHg),高于隔肌两侧压力差。结论:食管下段括约肌膈肌脚的收缩对胃食管返流均有拮抗作用。大白鼠腹段食管较长,是研究胃食管返流的理想模型。
Objective: To explore the antagonistic mechanism of gastroesophageal reflux. Methods: Thirty-three rats were subjected to esophageal manometry, the intrathoracic and abdominal pressure changes and their pressure differences during respiration were observed, the esophageal pressure curve was traced and their anatomical structures were observed. Results: The esophagus in the stomach of the rats was relatively long, and the intra-abdominal pressure was always higher than the intrathoracic pressure during the respiration. Pressure curve shows the lower esophageal sphincter pressure (LESP) and the diaphragm pressure on the foot of the esophagus (DPP), the former platform-like, the lower esophageal sphincter formation of the high pressure zone, the latter was wavy, wave frequency and respiratory rate Consistent, the distance between the two is equal to the length of abdominal esophagus, squeeze the esophagus due to diaphragm contraction. The experimental animals in both LESP and DPP accounted for 48.5%, only LESP or DPP accounted for 18.2% and 33.3%. The mean pressure of LESP and DPP were 2.32 ± 1.133 kPa (17.4 ± 8.5 mmHg) and 2.24 ± 1.04 kPa (16.8 ± 7.8 mmHg), higher than the pressure difference across the diaphragm. CONCLUSION: The contraction of the contralateral esophageal diaphragm muscle foot has antagonistic effect on gastroesophageal reflux. The longer esophagus in the stomach of the rats is an ideal model for studying gastroesophageal reflux.