烟碱是一种天然生物碱,早在十九世纪就被人们用作杀虫剂,但其杀虫活性低,并且对人畜有较高的毒性。拜耳公司以烟碱为先导化合物,成功开发出新烟碱类杀虫剂吡虫啉,随后该类杀虫剂取得了长足的发展,出现了噻虫嗪、噻虫胺、呋虫胺等商品化品种。缩氨基脲类化合物也是农药领域研究的热点,开发出了一些畅销的农药品种,如氰氟虫腙、茚虫威等。随着这两类杀虫剂的大量使用,害虫对其产生了较为严重的抗性,为了创制具有多靶标位点的新型农药,中国农业大学覃兆海课题组将新烟碱类与缩氨脲类杀虫剂的活性结构单元结合在一起,成功开发出了 Nicotine is a natural alkaloid that was used as an insecticide as early as the 19th century but has low insecticidal activity and high toxicity to humans and animals. Bayer company to nicotine as the lead compound, the successful development of a new nicotine insecticide imidacloprid, followed by such insecticide has made considerable development, appeared thiamethoxam, clothianidin, dinotefuran and other commercial varieties . Semicarbazide compounds are also the focus of research in the field of pesticides and some popular pesticide varieties have been developed, such as metaflumizone and indoxacarb. With the extensive use of these two types of insecticides, pests have a more serious resistance to them. In order to create a new type of pesticides with multiple target sites, the Chinese Agricultural University, Qin Zhaohai Task Force will neonicotinoid and mini-urea The insecticide’s active building blocks have been successfully developed