目的:研究沙棘总黄酮对4种念珠菌的体外抑菌作用。方法:采用醇提法从沙棘中提取其主要有效成分黄酮类化合物,用试管二倍稀释法联合琼脂平板法进行体外抑菌试验。结果:沙棘总黄酮对白色念珠菌、热带念珠菌、其他念珠菌的最小抑菌浓度(MIC)均为0.25g·L-1,对光滑念珠菌的MIC为0.5g·L-1。结论:沙棘总黄酮提取物对白色念珠菌、光滑念珠菌、热带念珠菌、其他念珠菌具有较好的抑制效果。 Objective: To study the antibacterial effect of total flavonoids of Hippophae rhamnoides on four Candida species in vitro. Methods: The main effective components of flavonoids were extracted from sea buckthorn by alcohol extraction method. In vitro antibacterial test was carried out by tube dilution method and agar plate method. Results: The minimum inhibitory concentration (MIC) of total flavonoids of Hippophae rhamnoides against Candida albicans, Candida tropicalis and Candida was 0.25 g·L-1, and the MIC of Candida glabrata was 0.5 g·L-1. Conclusion: The extract of sea buckthorn total flavonoids has a good inhibitory effect on Candida albicans, Candida glabrata, Candida tropicalis, and other Candida species.