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为进一步探讨糖尿病肾病（ＤＮ）的发病机理，更有效地防治ＤＮ，采用放射免疫分析法测定了３０例糖尿病（ＤＭ）、２６例ＤＮ和２７例肾脏疾病患者的血清肿瘤坏死因子（ＴＮＦ）含量，并与正常组对照。结果表明，ＤＭ血清ＴＮＦ测值为１．６３±０．２１μｇ／Ｌ，与对照组比较增高（Ｐ＜０．０５），ＤＮ组为２．６０±０．５１μｇ／Ｌ。显著高于正常（Ｐ＜０．０１），肾脏疾病组为２．６１±０．４３μｇ／Ｌ（Ｐ＜０．０１），增高与ＤＮ组无差异。从而明确了ＤＮ时血液循环中的ＴＮＦ明显增加，与细胞培养所得出的结论是一致的。
To further explore the pathogenesis of diabetic nephropathy (DN) and to prevent and treat DN more effectively, the levels of serum tumor necrosis factor (TNF) in 30 diabetic patients, 26 DN patients and 27 renal disease patients were measured by radioimmunoassay , And compared with the normal group. The results showed that the serum level of TNF was 1.63 ± 0.21 μg / L, which was significantly higher than that of the control group (P <0.05). The DN level was 2.60 ± 0.51 μg / L. Significantly higher than normal (P <0.01), renal disease group was 2.61 ± 0.43μg / L (P <0.01), no difference between DN group and DN group. It is clear that the DN when the blood circulation of TNF was significantly increased, and cell culture derived conclusions are consistent.