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本文观察了腺苷（ａｄｅｎｏｓｉｎｅ，Ａｄｏ）对小鼠非特异性免疫功能的影响，结果可见，Ａｄｏ１．３，１３，１３０ｍｇ·ｋｇ－１抑制３Ｈ胸腺脱氧嘧啶核苷（［３Ｈ］ＴｄＲ）参入的血液白细胞和腹腔巨噬细胞的吞噬功能，可减轻正常小鼠脾重，降低小鼠血清溶菌酶的含量，Ａｄｏ转运抑制剂潘生Ｔ１００ｍｇ·ｋｇ－１对Ａｄｏ１３０ｍｇ·ｋｇ－１的抑制作用无逆转作用。Ａｄｏ受体拮抗剂氨茶碱１０ｍｇ·ｋｇ－１可逆转Ａｄｏ１３０ｍｇ·ｋｇ－１的抑制作用，提示Ａ加ＡｄｏＡ２受体在腺苷的非特异性免疫反应中起重要作用。
In this paper, we observed the effect of adenosine (Ado) on non-specific immune function in mice. As a result, Ado1.3, 13 and 130 mg · kg-1 inhibited blood incorporation of 3H thymidine ([3H] TdR) Phagocytosis of leucocytes and peritoneal macrophages can reduce the spleen weight of normal mice, reduce the content of serum lysozyme, Ado transport inhibitor Pansheng T100mg · kg-1 has no effect on the inhibition of Ado130mg · kg-1 . Adoptive antagonist aminophylline 10mg · kg-1 can reverse the inhibitory effect of Ado130mg · kg-1, suggesting that A-AdoA2 receptor plays an important role in the nonspecific immune response to adenosine.