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目的：探索十六角蒙脱石和奥美拉唑合用的抗幽门螺旋杆菌（ＨＰ）与抗消化性溃疡的疗效。方法：将８５例经胃镜及ＨＰ检查证实的ＨＰ阳性消化性溃疡病人随机分为３组。Ａ组３２例口服十六角蒙脱石３ｇ，ｔｉｄ，加奥美拉唑２０ｍｇ，ｑｄ。Ｂ组２８例服十六角蒙脱石３ｇ，ｔｉｄ。Ｃ组２５例服奥美拉唑２０ｍｇ，ｑｄ。疗程均为４ｗｋ。治疗前、疗程结束时及结束４ｗｋ后分别做胃镜和ＨＰ检查。结果：Ａ，Ｂ，Ｃ３组溃疡愈合率分别为９４％，７８％和８８％，Ｐ＞０．０５。ＨＰ根除率分别为６２％，３２％和４％，Ｐ＜０．０５或０．０１。结论：联合用药的ＨＰ根除率高于２药单独使用。但对消化性溃疡疗效，２药联合与单独用药无显著差别。
Objective: To explore the efficacy of hexagonal montmorillonite and omeprazole combined with anti-helicobacter pylori (HP) and anti-peptic ulcer. Methods: 85 patients with HP-positive peptic ulcer confirmed by gastroscope and HP examination were randomly divided into 3 groups. A group of 32 oral hexagonal montmorillonite 3g, tid, plus omeprazole 20mg, qd. B group of 28 patients wear hexagonal montmorillonite 3g, tid. C group 25 cases of omeprazole 20mg, qd. Treatment are 4wk. Before treatment, end of treatment and end of 4wk were gastroscopy and HP were examined. Results: The healing rates of ulcer in groups A, B and C3 were 94%, 78% and 88%, respectively, P> 0.05. HP eradication rates were 62%, 32% and 4%, respectively, P <0.05 or 0.01. Conclusion: The combination therapy of HP eradication rate higher than the two drugs alone. However, the efficacy of peptic ulcer, 2 drug combination with no significant difference between the drug alone.