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目的观察比较NP(1～5天)与NP(1～8天)方案治疗非小细胞肺癌(NSCLC)的近期临床疗效和毒副作用。方法75例NSCLC患者随机分为NP(1～5天)组(38例)和NP(1～8天)组(37例),化疗3周期后比较近期疗效和毒副作用。结果NP(1～5天)组CR1例,PR15例,NP(1～8天)组CR0例,PR16例;总有效率NP(1～5天)方案为42.1%,NP(1～8天)方案为43.2%两组比较无显著性差异(P>0.05).主要毒副作用均为白细胞下降,Ⅲ-Ⅳ度发生率NP(1～5天)方案为18.4%,NP(1～8天)方案为16.2%;Ⅲ-Ⅳ度消化道反应两组相似(P>0.05)。结论NP(1～5天)方案与NSCLC近期疗效较NP(1～8天)治疗NSCLC无显著差异,毒副作用二组相似,但NP(1～5天)明显减少病人住院天数可以为病人减少不必要的经济损失,提高经济疗效,为医院提高病床周转率及节省卫生资源。
Objective To observe and compare the short-term clinical effects and side effects of NP (1-5 days) and NP (1-8 days) in the treatment of non-small cell lung cancer (NSCLC). Methods Seventy-five patients with NSCLC were randomly divided into NP (1-5 days) group (38 cases) and NP (1-8 days) group (37 cases). The efficacy and toxicity of 75 cases were compared after 3 cycles of chemotherapy. Results In NP (1-5 days) group, there were CR1 cases, PR15 cases and NP (1 ~ 8 days) cases in CR0 cases and PR16 cases. The total effective rate of NP (1-5 days) was 42.1% ) Was 43.2%, there was no significant difference between the two groups (P> 0.05) .The main toxic and side effects were leukopenia, the incidence of Ⅲ-Ⅳ NP (1-5 days) was 18.4% ) Program was 16.2%; Ⅲ-Ⅳ degree digestive tract reaction was similar between the two groups (P> 0.05). Conclusions There is no significant difference between NP (1 ~ 5 days) and NSCLC in the treatment of NSCLC. The toxicities and side effects are similar in the two groups. However, NP (1 ~ 5 days) significantly reduces the number of days hospitalized for patients with NSCLC. Unnecessary economic loss, improve economic efficiency, improve hospital bed turnover rate and save health resources.