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芳香酯酶(ArE/PON1)是一种含有巯基的钙依赖性酶,通过其N-末端富含疏水氨基酸残基与高密度脂蛋白相结合,在抗氧修饰脂蛋白和抗动脉粥样硬化中起重要作用。本研究主要探讨其192位基因多态性(ArE/PON1Q192R)在郑州地区2型糖尿病(DM)患者中的改变,为临床上防治DM及其并发心血管疾病提供理论基础。
Arylesterase (ArE / PON1) is a calcium-dependent sulfhydryl-containing enzyme that binds to high-density lipoproteins through the hydrophobic amino acid residues at the N-terminus. It is widely used in antioxidant modified lipoproteins and anti-atherosclerotic Play an important role. The aim of this study was to investigate the changes of 192 alleles (ArE / PON1Q192R) in patients with type 2 diabetes mellitus (DM) in Zhengzhou and to provide a theoretical basis for the prevention and treatment of DM and its associated cardiovascular diseases.