Many studies have investigated the evidence for tactile and visual interactive responses to activation of various brain regions.However,few studies have reported on the effects of visuo-tactile multisensory integration on the amount of brain activation on the somatosensory cortical regions.The aim of this study was to examine whether coincidental information obtained by tactile stimulation can affect the somatosensory cortical activation using functional MRI.Ten right-handed healthy subjects were recruited for this study.Two tasks(tactile stimulation and visuotactile stimulation)were performed using a block paradigm during f MRI scanning.In the tactile stimulation task,in subjects with eyes closed,tactile stimulation was applied on the dorsum of the right hand,corresponding to the proximal to distal directions,using a rubber brush.In the visuotactile stimulation task,tactile stimulation was applied to observe the attached mirror in the MRI chamber reflecting their hands being touched with the brush.In the result of SPM group analysis,we found brain activation on the somatosensory cortical area.Tactile stimulation task induced brain activations in the left primary sensory-motor cortex(SM1)and secondary somatosensory cortex(S2).In the visuo-tactile stimulation task,brain activations were observed in the both SM1,both S2,and right posterior parietal cortex.In all tasks,the peak activation was detected in the contralateral SM1.We examined the effects of visuo-tactile multisensory integration on the SM1 and found that visual information during tactile stimulation could enhance activations on SM1 compared to the tactile unisensory stimulation. Many studies have investigated the evidence for tactile and visual interactive responses to activation of various brain regions. Yet, a few studies have reported on the effects of visuo-tactile multisensory integration on the amount of brain activation on the somatosensory cortical regions. The aim of this study was to examine whether coincidental information obtained by tactile stimulation can functional the somatosensory cortical activation using functional MRI. Right-handed healthy subjects were recruited for this study. Two tasks (tactile stimulation and visuotactile stimulation) were performed using a block paradigm during f MRI scanning. The subjects with eyes closed, tactile stimulation was applied on the dorsum of the right hand, corresponding to the proximal to distal directions, using a rubber brush. The visuotactile stimulation task, tactile stimulation was applied to observe the attached mirror in the MRI chamber reflecting their hands being touched w ith the brush. the result of SPM group analysis, we found brain activation on the somatosensory cortical area. Tissue stimulation task induced brain activations in the left primary sensory-motor cortex (SM1) and secondary somatosensory cortex (S2). In the visuo -tactile stimulation task, brain activations were observed in the both SM1, both S2, and right posterior parietal cortex. All tasks, the peak activation was detected in the contralateral SM1.We examined the effects of visuo-tactile multisensory integration on the SM1 and found that visual information during tactile stimulation could enhance activations on SM1 compared to the tactile unisensory stimulation.