论文部分内容阅读
目的:观察前列地尔在糖尿病肾病大量蛋白尿期的临床治疗效果。方法:选取确诊为唐念冰肾病患者,随机分为对照组、前列地尔治疗组,治疗疗程12周。观察观察两组患者治疗前后尿素氮、血肌酐和24小时尿微量白蛋白、总蛋白的变化。结果:前列地尔组治疗前后相比,24小时尿总蛋白及尿微量白蛋白明显下降(P<0.05)。前列地尔组治疗后与相应的对照组治疗后相比,24小时尿总蛋白及尿微量白蛋白也有明显下降(P<0.05)。结论:应用前列地尔治疗大量蛋白尿期糖尿病肾病患者能显著减少尿蛋白,值得在临床推广应用。
Objective: To observe the clinical therapeutic effect of alprostadil in massive proteinuria of diabetic nephropathy. Methods: Selected patients who were diagnosed as Tang Bing Bing Nei were randomly divided into control group and alprostadil treatment group for 12 weeks. The changes of urea nitrogen, serum creatinine and 24-hour urine microalbumin and total protein in two groups before and after treatment were observed. Results: Total urinary albumin and urine total protein and urinary albumin decreased significantly (P <0.05) 24 hours after treatment in the alprostadil group. Compared with the corresponding control group after treatment, the total urinary albumin and urinary albumin in 24 hours after treatment in the alprostadil group also decreased significantly (P <0.05). Conclusion: The application of alprostadil in treatment of massive proteinuria in diabetic nephropathy patients can significantly reduce urinary protein, it is worth in the clinical application.