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目的:探讨抗抑郁治疗对经皮冠状动脉介入治疗术后并抑郁症的不稳定型心绞痛患者心血管事件发生率的影响。方法:经皮冠状动脉介入治疗术后并抑郁症不稳定心绞痛患者78例,随机分为治疗组(38例)和对照组(40例),对照组给予常规治疗,治疗组在常规治疗基础上给予心理治疗加用抗抑郁药黛力新,2片/d,口服,疗程6个月,比较2组心血管事件发生率。结果:治疗组心绞痛、心力衰竭、短阵室性心动过速发生率低于对照组(P<0.05),6min步行试验,左室射血分数较对照组改善明显(P<0.05)。结论:抗抑郁治疗能降低经皮冠状动脉介入治疗术后并抑郁症患者心血管事件发生率,改善预后。
Objective: To investigate the effect of antidepressant treatment on the incidence of cardiovascular events in patients with unstable angina pectoris after percutaneous coronary intervention and depression. Methods: A total of 78 patients with unstable angina pectoris after percutaneous coronary intervention were randomly divided into treatment group (38 cases) and control group (40 cases). The control group was given routine treatment. The treatment group was treated on the basis of routine treatment Give psychological treatment with antidepressants Deanxit, 2 tablets / d, oral, treatment for 6 months, the incidence of cardiovascular events in two groups were compared. Results: The incidence of angina pectoris, heart failure and paroxysmal ventricular tachycardia in the treatment group was lower than that in the control group (P <0.05). The left ventricular ejection fraction was significantly improved in the 6-minute walking test (P <0.05). Conclusions: Antidepressant therapy can reduce the incidence of cardiovascular events and reduce the prognosis of patients with depression and after percutaneous coronary intervention.