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目的探讨米非司酮治疗子宫内膜异位症患者的效果及作用机制。方法随机选取2012年8月至2013年2月吉林省白山市通济医院收治的子宫内膜异位症患者资料54例,均为于月经第1天口服米非司酮12.5 mg,1次/d,连续用药6个月。分别观察治疗前及治疗6个月后患者的临床症状、体征评分,评价治疗效果,并观察不良反应发生情况;停止用药后随访1年,观察妊娠结局、复发情况,并监测性激素水平。结果 54例患者月经均恢复正常,疗效判定结果:缓解29例,改善19例,无效6例,治疗有效率为88.9%,其中2例继发不孕患者妊娠2个月;治疗前及治疗6个月后患者孕酮、催乳素、血清卵泡刺激素、促黄体生成素、促肾上腺皮质激素水平比较,差异均无统计学意义(均P>0.05),治疗6个月后雌二醇水平明显高于治疗前,差异有统计学意义(P<0.05)。无1例出现严重不良反应。结果小剂量米非司酮治疗子宫内膜异位症,可有效改善机体激素水平,改善患者的临床症状,应用安全可靠。
Objective To investigate the efficacy and mechanism of mifepristone in patients with endometriosis. Methods A total of 54 patients with endometriosis admitted to Tongji Hospital of Baishan City, Jilin Province from August 2012 to February 2013 were selected randomly and received mifepristone 12.5 mg once daily on the first day of menstruation. d, continuous medication for 6 months. The clinical symptoms and signs of patients before and 6 months after treatment were observed, the therapeutic effect was evaluated, and the incidence of adverse reactions was observed. The patients were followed up for 1 year after stopping the treatment to observe the pregnancy outcome and recurrence and to monitor the levels of sex hormones. Results All 54 patients returned to normal menstruation. Results of curative effect evaluation showed that 29 cases were relieved, 19 cases were improved and 6 cases were ineffective. The effective rate was 88.9%, of which 2 cases of secondary infertility were pregnant for 2 months. Before treatment and 6 After 6 months, the levels of progesterone, prolactin, serum FSH, luteinizing hormone and adrenocorticotropic hormone were not significantly different (all P> 0.05), and the level of estradiol was obvious after 6 months of treatment Higher than before treatment, the difference was statistically significant (P <0.05). No one case of serious adverse reactions. Results Small dose of mifepristone treatment of endometriosis, can effectively improve the body’s hormone levels, improve the clinical symptoms of patients, the application of safe and reliable.