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随着耐多药革兰阴性菌的日趋流行,多黏菌素B的应用受到新的关注,但目前对该药的肾毒性特征还知之甚少,且由于纳入人群、给药途径、给药剂量等差异,目前的研究报道中关于多黏菌素的肾毒性发生率也不一致。本研究目的在于探索多黏菌素B的肾毒性特征,并着眼于给药频率对肾毒性的影响。方法:体外毒性试验采用3种离体肾细胞(大鼠的近曲小管上皮细胞,犬的远曲小管上皮细胞,人胚胎肾细
With the increasing prevalence of multidrug-resistant Gram-negative bacteria, the use of polymyxin B has received new attention, but little is known about the nephrotoxicity profile of this drug, and because of inclusion in the population, route of administration, administration Dose differences, the current report on the incidence of polymyxin nephrotoxicity is not the same. The purpose of this study was to explore the characteristics of nephrotoxicity of polymyxin B and focus on the effect of administration frequency on nephrotoxicity. METHODS: In vitro toxicity assay was performed using three kinds of isolated renal cells (proximal tubule epithelial cells of rats, far tubule epithelial cells of dogs,