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研究与对比了螯合剂8102与DTPA和碳酸氢钠在ICR小鼠体内促排浓缩铀的效果,以及不同剂量的8102促排浓缩铀的效果。结果显示,8102促排效果优于DTPA和碳酸氢钠。当剂量为400mg/kg时,排除量可占摄入量的86.6％,生物半排期由对照组的79.7h降至28.1h。主要蓄积器官内的浓缩铀的滞留量与对照组相应器官的相对比,肾脏仅为0.247,肝脏为0.259,骨骼为0.370。此外,8102还具有明显的缓解浓缩铀急性中毒的毒性反应。在观察期间实验组动物无因染毒而死亡,而对照组在观察终点的死亡率近100％。延时30min给药仍有较好的促排疗效。
The effect of chelator 8102, DTPA and sodium bicarbonate on promoting uranium enrichment in ICR mice and the effect of different doses of uranium enrichment on 8102 were studied and compared. The results show that 8102 is better than DTPA and sodium bicarbonate. When the dose was 400mg / kg, the exclusion could account for 86.6% of the intake, and the biological half-life decreased from 79.7h to 28.1h in the control group. The accumulation of enriched uranium in the main organs was only 0.247 in the kidney, 0.259 in the liver and 0.370 in the bones compared with the corresponding organs in the control group. In addition, 8102 also has significant toxicity to alleviate the acute toxicity of enriched uranium toxicity. During the observation period, the animals in the experimental group died of exposure to the drug, while the control group had nearly 100% mortality at the end of the observation period. Delay 30min administration is still a better promotion of curative effect.