论文部分内容阅读
目的 研究遗传性非息肉病性大肠癌 (HNPCC)在大肠癌中的比例及临床病理特点。方法 收集和分析 5 5 0例大肠癌的临床病理及随访资料 ,符合Amsterdam标准或日本标准者诊断为HNPCC。结果 5 5 0例大肠癌中 6例 (1 1 % )符合Amsterdam标准 ,1 9例 (3 5 % )符合日本标准。本组HNPCC的临床病理特点是肿瘤发病年龄早 ,多位于右半结肠 ,粘液癌及多原发大肠癌多见 ,家族中肠外肿瘤增多 ,息肉伴随增多不明显。结论 HNPCC具有特殊的临床病理特点 ,本组HNPCC在结肠癌中的比例与国外资料类似
Objective To investigate the proportion and clinical pathological features of hereditary nonpolyposis colorectal cancer (HNPCC) in colorectal cancer. Methods The clinical pathology and follow-up data of 550 colorectal cancers were collected and analyzed. Those who met the Amsterdam standard or Japanese standard were diagnosed as HNPCC. Results Of 550 colorectal cancers, 6 (11%) met the Amsterdam criteria, and 19 (35%) met the Japanese criteria. The clinicopathologic features of HNPCC in this group were early onset of the tumor, mostly in the right colon, mucinous carcinoma and multiple primary colorectal cancers were more common, and there was an increase in extra-intestinal tumours in the family, with no significant increase in polyps. Conclusion HNPCC has special clinicopathological features. The proportion of HNPCC in colon cancer is similar to that of foreign countries.