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目的研究强直性脊柱炎(AS)与感染的关系。方法横断面研究188例住院AS患者的呼吸道、泌尿生殖和胃肠道等感染状况,分析其与血红细胞沉降率(ESR)、C反应蛋白(CRP)和疾病活动的关系,统计方法采用χ2检验。结果 AS总体临床感染率为59.6%,有呼吸道感染比例为39.9%,已婚者和未婚者泌尿生殖道感染为24.2%和12.5%,胃肠道感染为9.0%;其中总体感染和呼吸道感染与CRP升高的患者例数(χ2分别为5.7和4.26,P分别为0.017和0.039)、活动期例数(χ2分别为5.96和13.4,P分别为0.015和0.0003)密切相关,呼吸道感染还与血沉升高有关(χ2=4.24,P=0.04);胃肠道和泌尿生殖道感染与血沉、CRP和疾病活动例数无关。结论呼吸道感染是导致AS疾病活动的危险因素之一,但泌尿生殖系统感染和胃肠道感染与疾病活动无关。
Objective To study the relationship between ankylosing spondylitis (AS) and infection. Methods The cross-sectional study of respiratory tract, genitourinary and gastrointestinal infections in 188 hospitalized AS patients was performed to analyze the relationship between erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and disease activity. The statistical method wasχ2 test . Results The overall clinical infection rate of AS was 59.6%, the rate of respiratory infection was 39.9%, the genitourinary tract infections of married and unmarried persons were 24.2% and 12.5%, and the incidence of gastrointestinal infections was 9.0%. The overall infection and respiratory infection were The number of patients with elevated CRP (χ2 = 5.7 and 4.26, P = 0.017 and 0.039, respectively) was significantly associated with the number of active cases (χ2 = 5.96 and 13.4, P = 0.015 and 0.0003, respectively) (Χ2 = 4.24, P = 0.04). Gastrointestinal and urogenital infections were not associated with ESR, CRP and the number of disease activities. Conclusions Respiratory tract infection is one of the risk factors leading to AS disease activity, but genitourinary tract infection and gastrointestinal tract infection have nothing to do with disease activity.