本文观察基因工程干扰素α-2b治疗36例慢性乙型肝炎患者甲襞微循环改变，分析患者肝脏微循环与α-干扰素治疗的关系、结果表明甲襞微循环形态积分，流态积分，襻周积分和总积分值，治疗后明显降低（p＜0.01）。α-干扰素治疗后患者的微循环障碍程度如管襻不清晰、管襻数减少、交叉畸形增多、输入枝、襻顶、输出校变细、血流速度减慢及红细胞聚集等均有明显改善。同时发现微循环改善与肝功能改善有明显的相关性。 This article observed the genetic engineering interferon α-2b treatment of 36 cases of chronic hepatitis B patients with nailfold microcirculation changes in patients with liver microcirculation and interferon-alpha treatment, the results show that formazan microcirculation morphology integral, flow integral, Weekly points and total points were significantly lower after treatment (p <0.01). The level of microcirculation in patients with a-interferon after treatment was unclear, such as unclear tube, reduced tube count, increased cross deformity, input branches, apex, output correction fine, slowed blood flow and erythrocyte aggregation were obvious improve. Also found that improvement of microcirculation and liver function improved significantly.