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目的:探讨米力农对老年心力衰竭患者心功能及血清hs-CRP、TNF-α、IL-6水平的影响。方法:将72例老年慢性心力衰竭患者随机分为观察组(n=36)与对照组(n=36),对照组给予常规抗心衰治疗,观察组患者联合应用米力农治疗,比较两组患者临床疗效及治疗前后心功能指标(超声心动图、血清NT-pro BNP)及血清hs-CRP、TNF-α、IL-6水平的变化。结果:治疗后,观察组治疗总有效率为91.67%,较对照组(75.00%)明显升高,差异有有统计学意义(P<0.05);与治疗前比较,LVEF在两组患者均获得了明显升高LVEDd及血清NT-pro BNP水平明显下降,观察组患者上述指标均优于对照组患者(P<0.05);治疗后,血清hs-CRP、TNF-α及IL-6水平在两组患者均降低明显,且观察组上述指标明显低于对照组,差异均有统计学意义(P<0.05)。结论:短期使用米力农治疗老年慢性心力衰竭患者,可以明显改善患者的心功能、抑制炎症反应、提高临床疗效。
Objective: To investigate the effects of Milrinone on heart function, serum hs-CRP, TNF-α and IL-6 levels in elderly patients with heart failure. Methods: Seventy-two elderly patients with chronic heart failure were randomly divided into observation group (n = 36) and control group (n = 36). The control group was given conventional anti-heart failure treatment. The observation group was treated with Milrinone. (Echocardiography, serum NT-pro BNP), serum hs-CRP, TNF-α, IL-6 levels before and after treatment in the treatment group. Results: After treatment, the total effective rate of the observation group was 91.67%, which was significantly higher than that of the control group (75.00%), the difference was statistically significant (P <0.05); LVEF was obtained in both groups before treatment (P <0.05). After treatment, the levels of hs-CRP, TNF-α and IL-6 in the two groups were significantly lower than those in the control group The patients in the two groups were significantly lower than those in the control group, and the differences were statistically significant (P <0.05). Conclusion: Short-term use of milrinone in elderly patients with chronic heart failure can significantly improve the patient’s cardiac function, inhibit the inflammatory response and improve clinical efficacy.