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目的探讨饮食控制和运动疗法对肥胖儿童血清抵抗素水平的影响及其临床意义。方法测定36例肥胖儿童饮食控制和运动治疗前后血清抵抗素、胆固醇(CHO)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL_C)、空腹和葡萄糖耐量试验(OGTT)2小时血糖、胰岛素,计算胰岛素抵抗指数(HOMA_IR)。结果肥胖儿童血清抵抗素水平显著高于对照组(P<0.05),并与OGTT2小时血糖、胰岛素呈正相关(P<0.05);经饮食控制和运动治疗后肥胖儿童血清抵抗素、体重、BMI、血清CHO、TG、LDL_C、空腹和OGTT2小时胰岛素、HOMA_IR显著低于治疗前(P<0.05),治疗前后空腹和OGTT2小时血糖差异无显著性(P>0.05)。结论肥胖儿童血清抵抗素水平升高,并与OGTT2小时血糖、胰岛素呈正相关,推测将来有可能以检测血清抵抗素水平来了解肥胖儿童有否存在糖耐量受损;饮食控制和运动疗法可使肥胖儿童血清抵抗素降低,胰岛素抵抗减轻。
Objective To investigate the effects of diet control and exercise therapy on serum resistin in obese children and its clinical significance. Methods Serum levels of resistin, cholesterol (CHO), triglyceride (TG), low density lipoprotein cholesterol (LDL_C), fasting glucose and glucose tolerance test (OGTT) , Calculated insulin resistance index (HOMA_IR). Results The levels of serum resistin in obese children were significantly higher than those in the control group (P <0.05), and were positively correlated with the hour 2 OGTT (P <0.05). The serum levels of resistin, body weight, Serum CHO, TG, LDL_C, fasting and OGTT 2 h insulin, HOMA_IR were significantly lower than those before treatment (P <0.05). There was no significant difference in fasting blood glucose and OGTT 2 h before and after treatment (P> 0.05). Conclusion Overexpression of serum resistin in Obese children is positively correlated with OGTT 2-hour blood glucose and insulin, suggesting that it is possible to detect whether there is impaired glucose tolerance in obese children by detecting serum resistin level in the future. Diet control and exercise therapy may obesity Children’s serum resistin decreased, insulin resistance reduced.