通过对１９９０年上海发生的“６．２５”６０Ｃｏ源辐射事故所致的５名骨髓型急性放射病患者系统随访观察，探讨电离辐射引起的远后效应及其性质程度和与剂量的关系等。方法持续６年对患者进行临床表现、造血功能、染色体畸变、免疫功能、神经系统、内分泌功能、生殖功能及眼晶体等检查和ＨＰＲＴ基因突变及某些癌基因检测。结果发现患者在上述诸方面仍存在不同程度辐射损伤，部分损伤程度与受照剂量有关。结论本组患者的研究结果，不仅为患者的医疗保健提供了依据，而且为人的骨髓型急性放射病远后效应研究提供了可靠信息和积累宝贵资料。 A systematic follow-up of 5 patients with acute myeloid leukemia caused by the “6.25” 60Co radiation accident in Shanghai in 1990 was conducted to investigate the far-after effects caused by ionizing radiation and their relationship with the dosage. Methods The clinical manifestations, hematopoiesis, chromosomal aberrations, immune function, nervous system, endocrine function, reproductive function, ocular lens and other tests and HPRT gene mutation and some oncogenes were detected in the patients for 6 years. The results found that patients in these areas there are still varying degrees of radiation damage, some of the damage and dose-related. Conclusions The findings of this study not only provide the basis for the patients’ medical care, but also provide reliable information and accumulate valuable information for the study of the far-end effect of human bone marrow acute radiation sickness.