抗生素的抑菌效能现在普遍采用抗生素的最小抑菌浓度(MIC)作为指标,临床上也以MIC和血清浓度作为用药的依据。本文作者提出了双个体化数学检测原理,即把抗生素的药动学和细菌敏感性的变化作为一整体来研究,以描述在抗生素血清浓度变化过程中细菌的清除率。与此原理有关的药动学参数有:抑菌商(C_(max)/MIC),最低抑菌浓度以上的血清浓度-时间曲线下面积(AUCaboveMIC)和时间(Time above MIC),杀菌效价曲线下面积(AUBC),及抑菌曲线下面积 Antibiotics antibacterial efficacy now commonly used antibiotics minimum inhibitory concentration (MIC) as an indicator, clinically MIC and serum concentration as a basis for medication. The authors propose a dual self-contained mathematical test that examines changes in antibiotic pharmacokinetics and bacterial susceptibility as a whole to account for bacterial clearance during antibiotic serum concentrations. Pharmacokinetic parameters related to this principle are: antibacterial quotient (C max / MIC), serum concentration-time under MIC (AUCaboveMIC) and time above (MIC), bactericidal titer Area under the curve (AUBC), and area under the antibacterial curve