人尿激酶原(pro-UK,又称单链尿激酶)由于具有较好的选择性溶血栓作用而又不引起全身系统性出血,近年来受到国内外学者重视。但自尿中提取含量极少,较有希望的途径是通过基因工程手段来制备,pro-UK含411个氨基酸加上20个氨基酸的信号肽,全长基因编码序列为1293bp。要获得这样较大的cDNA基因有一定难度。国外虽已有几家公司报道他们克隆了pro-UK cDNA基因,但国内尚无报道。1988年我 Human pro-UK (pro-UK, also known as single-chain urokinase) due to the better selective thrombolytic effect without causing systemic systemic bleeding, in recent years by domestic and foreign scholars attention. However, very little from the urine extraction, the more promising way is to prepare by genetic engineering, pro-UK contains 411 amino acids plus 20 amino acid signal peptide, the full-length gene coding sequence is 1293bp. There is some difficulty in getting such a large cDNA gene. Although several foreign companies reported that they cloned the pro-UK cDNA gene, but no reports have been made in China. I am in 1988