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目的:探讨帕金森病(PD)患者的压力反射敏感性(BRS)的受损及体位改变的影响。方法:对正常青年组13名,正常老年组11名,PD组16例,采用频谱分析的方法检测仰卧(supine)和头高位倾斜(HUT,+75°)时的心率变异性(HRV)和BRS值。结果:Supine在PD组BRS较青年组低(P<0.05);HUT后各组BRS均降低(P<0.05),且各组之间的差异显著,青年组、老年组、PD组依次降低(P<0.05)。结论:体位改变使BRS值降低;PD患者的心血管反射受损;BRS及体位改变测试是PD患者自主神经功能损害的敏感指标。
Objective: To investigate the effects of baroreflex (BRS) damage and changes of position in Parkinson’s disease (PD) patients. Methods: Thirteen normal young group, eleven normal aged group and 16 PD group were enrolled in this study. Heart rate variability (HRV) at supine and head elevation (HUT, + 75 °) and BRS value. Results: Supine was lower in PD group than that in young group (P <0.05); BRS in each group decreased after HUT (P <0.05), and there was significant difference between groups P <0.05). CONCLUSIONS: Postural changes reduce BRS values; impaired cardiovascular reflexes in PD patients; and BRS and postural change tests are sensitive markers of autonomic dysfunction in PD patients.