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糖尿病足是糖尿病最严重的和治疗费用最高的慢性并发症之一,严重者可以导致截肢。其中,大约85%的截肢是由于足溃疡引发的,严重影响了患者生活质量,给社会带来了沉重的经济负担。外周动脉病变是造成糖尿病足的一个重要因素,大多合并严重外周动脉病变的患者会发生足溃疡,导致伤口愈合延缓,增加了治疗难度。临床证实,对糖尿病足溃疡实施局部治疗可以缓解病灶疼痛,预防感染发生。不过,迄今为止,改善受损组织灌注仍是外周动脉疾病治疗面临的重大挑战。就治疗而言,伴有局部动脉狭窄的患者往往需要接受介入血管成形术或血管外科手术,而伴有严重下肢缺血且不能行血管重建的患者预后相对较差,往往面临截肢的风险。值得庆幸的是,经过多年临床实践,上述治疗方法有了很大改进。当前,治疗目的在于改善患者下肢灌注,发展以干细胞技术为基础的新型尖端疗法。流行病学统计资料显示,糖尿病足患者中高达4%的人会面临大截肢,需要广大医生和患者引起密切关注。
Diabetic foot is one of the most serious and costly chronic complications of diabetes, and severe cases can lead to amputation. Of these, about 85% of amputations are caused by foot ulcers, seriously affecting the quality of life of patients and posing a heavy financial burden on the community. Peripheral artery disease is an important factor contributing to diabetic foot, most patients with severe peripheral arterial disease foot ulcers occur, leading to delayed wound healing, increasing the difficulty of treatment. Clinically proven that the implementation of local treatment of diabetic foot ulcer lesions can ease pain and prevent infection. However, so far, improving impaired tissue perfusion remains a significant challenge for the treatment of peripheral arterial disease. In terms of treatment, patients with localized arterial stenosis often require interventional angioplasty or vascular surgery, whereas patients with severe lower limb ischemia who can not undergo revascularization have a poorer prognosis and often face the risk of amputation. Fortunately, after years of clinical practice, the above treatment has been greatly improved. Currently, the goal of treatment is to improve patient perfusion of the lower limbs and to develop new cutting-edge therapies based on stem cell technology. Epidemiological statistics show that up to 4% of diabetic foot patients face large amputation, requiring the doctor and the patient to pay close attention.