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目的：为探讨慢性乙型肝炎病毒性肝病患者血清细胞团子TNF-α、IL-1、IL-6、IL-8活性变化及其在慢性肝病发生发展中的作用及临床意义。方法：采用ELISA法对慢性乙型肝炎（CH）、慢性乙型重型肝炎（CSH）、乙型肝炎性肝硬化（HC）患者血清中细胞因子TNF-α、IL-1、IL-6、IL-8活性进行了测定。结果：慢肝患者血清INF-α、IL-1、IL-6、IL-8水平明显高于健康对照组（P＜0．01）；以上4种细胞因子活性与不同临床类型的慢肝患者血清胆红素含量平行测定二者呈正相关；HBV-DNA或HBeAg阳性患者上述细胞因子活性明显高于HBV-DNA、HBeAg阴性患者（P＜0．01）。结论：慢性病毒性肝病患者机体存在免疫功能调控失衡；细胞因子活性与血清胆红素同样可反映肝细胞损伤程度；细胞因子TNF-α、IL-1、IL-6、IL-8活性与患者HBV携带状态即HBV的活跃程度有关。
OBJECTIVE: To investigate the changes of the activity of TNF-α, IL-1, IL-6 and IL-8 in serum cell clusters and their roles in the development of chronic liver disease in patients with chronic hepatitis B and their clinical significance. Methods: Serum levels of TNF-α, IL-1, IL-6, IL were measured by ELISA in patients with chronic hepatitis B, chronic severe hepatitis B and chronic hepatitis B cirrhosis, -8 activity was measured. Results: The serum levels of INF-α, IL-1, IL-6 and IL-8 in patients with chronic liver disease were significantly higher than those in healthy controls (P <0.01). The activity of these four cytokines was significantly different from those in patients with chronic liver disease Serum bilirubin levels were positively correlated with each other. The cytokine activity of HBV-DNA or HBeAg-positive patients was significantly higher than that of HBV-DNA and HBeAg-negative patients (P <0.01). Conclusion: There is imbalance of immune function in the body of patients with chronic viral liver disease. Cytokine activity and serum bilirubin also reflect the degree of hepatocyte injury. The activity of cytokines TNF-α, IL-1, IL-6 and IL- The status of HBV activity.