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目的:探讨原发性癫全身强直—阵挛发作患者单次痫性发作后不同时段的脑电图阳性检出率及其与大脑神经元的损伤之间的关系。方法:对60例原发性癫全身强直-阵挛发作患者分别于间歇期、单次痫性发作第1、2、3、5、10天分别进行脑电图检查及血清神经元特异性烯醇酶(NSE)检测,并检测50名正常人的血清NSE含量作为对照。结果:60例患者痫性发作间歇期、发作第1、2、3、5、10天的脑电图阳性率分别为46.7%、51.7%、55.0%、76.7%、68.3%、48.3%。第3、5天脑电图阳性率与间歇期比较差异有统计学意义(P<0.05),以第3天最高。与间歇期比较,血清NSE含量以发作第2天最高,第3天开始下降,第5天降至正常水平。结论:单次癫全身强直—阵挛发作对大脑神经元有损伤,痫性发作后第3、5天脑电图异常率较间歇期增高,可能是由于受损脑神经细胞在修复过程中兴奋性增强、膜电位不稳定,导致异常放电发生率增高。
Objective: To investigate the positive detection rate of EEG at different time points after single seizure onset in patients with primary epileptic tonic-clonic seizures and its relationship with neuronal damage in the brain. Methods: Sixty patients with primary epileptic tonic-clonic seizures were subjected to electroencephalogram (EEG) and serum neuron-specific enolase Alcohol enzyme (NSE) test, and detect the serum NSE levels of 50 normal people as a control. Results: The positive rates of electroencephalography (EEG) on the 1st, 2nd, 3rd, 5th and 10th days were 60.7%, 51.7%, 55.0%, 76.7%, 68.3% and 48.3%, respectively. The positive rate of electroencephalogram on the 3rd and 5th day was significantly different from that on the intermission (P <0.05), and the highest on the 3rd day. Compared with the intermittent phase, serum NSE levels were highest on the second day of the attack, decreased on the third day, and dropped to normal levels on the fifth day. CONCLUSIONS: Single epilepsy tonic-clonic seizures have impaired neurons in the brain. EEG abnormalities increased on the 3rd and 5th day after epileptic seizures compared with the intermission, which may be due to the excitement of impaired brain neurons in the repair process Sex enhancement, unstable membrane potential, resulting in increased incidence of abnormal discharge.