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目的探讨过敏性紫癜(HSP)与儿童急性白血病的关系。方法回顾性分析2000年1月-2011年6月17例儿童急性白血病合并HSP患儿的临床资料。对17例年龄为(8.75±0.45)岁的急性白血病并HSP患儿进行临床分型及治疗,应用Fisher’s确切概率法对急性白血病并HSP发生时间与化疗是否有关进行统计分析。结果急性白血病患儿并HSP的发生在确诊白血病后出现的频率最高(14/17例),其中ALL占比例较高(9/14例),儿童急性白血病并HSP的发生与化疗无明显相关性。结论急性白血病患儿并HSP是否发生在确诊白血病后还有待进一步研究。
Objective To investigate the relationship between Henoch-Schonlein purpura (HSP) and childhood acute leukemia. Methods The clinical data of 17 children with acute leukemia and HSP were retrospectively analyzed from January 2000 to June 2011. Seventeen patients (8.75 ± 0.45) years old with acute leukemia and HSP were enrolled in the clinical classification and treatment. Fisher’s exact test was used to analyze whether the occurrence of acute leukemia and HSP were related to chemotherapy. Results The incidence of HSP in children with acute leukemia was the highest (14/17 cases) after the diagnosis of leukemia, with a high proportion of ALL (9/14 cases). There was no significant correlation between the occurrence of HSP in children with acute leukemia and chemotherapy . Conclusions Children with acute leukemia and HSP after the diagnosis of leukemia remains to be further studied.