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目的研究阿托伐他汀钙对急性脑梗死患者血清C-反应蛋白(CRP)水平和脑梗死复发的影响。方法选择65例急性脑梗死患者,随机分成2组:对照组32例,常规治疗;阿托伐他汀钙组33例在常规治疗的基础上加用阿托伐他汀钙。分别在治疗前及治疗14、30、60、180、360d等时间段采集静脉血,测定血清CRP浓度,统计两组患者1年内脑梗死复发的例数。结果治疗后对照组及阿托伐他汀钙组血清CRP水平均较治疗前明显下降,且阿托伐他汀钙组血清CRP水平明显低于同期对照组,并把血清CRP水平维持在较低位置,降低了脑梗死的复发率,差异具统计学意义。结论阿托伐他汀钙可明显降低缺血性卒中患者的血清CRP水平,并具有抗炎作用,能将CRP水平维持在较低的位置,降低了脑梗死复发率。
Objective To study the effect of atorvastatin calcium on serum C-reactive protein (CRP) level and the recurrence of cerebral infarction in patients with acute cerebral infarction. Methods Sixty-five patients with acute cerebral infarction were randomly divided into two groups: control group (n = 32) and routine treatment; and atorvastatin calcium group (n = 33) were given atorvastatin calcium on the basis of routine treatment. Venous blood was collected before treatment and at 14, 30, 60, 180, 360 days, respectively. Serum CRP levels were measured. The number of recurrent cases of cerebral infarction in two groups was calculated. Results After treatment, serum CRP levels in control group and atorvastatin calcium group were significantly lower than those before treatment, and serum CRP level in atorvastatin calcium group was significantly lower than that in the control group, and serum CRP level was maintained at a lower position, Reduce the recurrence rate of cerebral infarction, the difference was statistically significant. Conclusions Atorvastatin calcium can significantly reduce serum CRP level in patients with ischemic stroke and has anti-inflammatory effects. It can maintain the CRP level at a lower level and reduce the recurrence rate of cerebral infarction.