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目的研究本地区女性不孕症患者生殖道支原体感染现状,检测分析其对12种抗菌药物的敏感情况,使支原体感染的治疗更具针对性。方法对本地区女性不孕症患者436例进行生殖道分泌物采样,将标本作支原体检测及药敏分析。结果 436例女性不孕症患者生殖道分泌物标本中,支原体感染211例(占48.4%),解脲脲原体感染171例(占39.2%),人型支原体感染19例(占4.4%),两者混合感染21例(占4.8%)。药敏结果显示多西环素敏感性最强(90.5%),其次为美满霉素(86.3%)、交沙霉素(85.8%)、克拉霉素(85.3%)、阿奇霉素(78.2%)。而环丙沙星耐药性最高(64.5%)、其次为氧氟沙星(36.5%)、左旋氧氟沙星(36.0%)、螺旋霉素(35.6%)。结论患者中支原体感染率较高,是引起女性不孕症的主要原因之一,根据支原体培养及药敏检测结果,合理规范地选择使用抗菌药物,对不孕症诊治有着重要的临床价值。
Objective To study the prevalence of mycoplasma genitalium infection in female infertility patients in this area and to detect and analyze its sensitivity to 12 kinds of antimicrobial agents so that the treatment of mycoplasma infection can be more targeted. Methods A total of 436 female infertility patients in this area were collected for genital tract secretions. The specimens were tested for mycoplasma and drug sensitivity analysis. Results Among 436 female infertility patients, 211 were mycoplasma infection (accounting for 48.4%), 171 were Ureaplasma urealyticum (39.2%), 19 were Mycoplasma hominis (4.4%), 21 cases (4.8%) were mixed infection. Susceptibility results showed that doxycycline was the most sensitive (90.5%), followed by minocycline (86.3%), jasamycin (85.8%), clarithromycin (85.3%) and azithromycin (78.2%). Ciprofloxacin was the most resistant (64.5%), followed by ofloxacin (36.5%), levofloxacin (36.0%) and spiramycin (35.6%). Conclusion The higher prevalence of mycoplasma in patients is one of the main causes of infertility in women. According to the results of mycoplasma culture and drug susceptibility testing, rational and standardized selection of antimicrobial agents has important clinical value in diagnosis and treatment of infertility.