论文部分内容阅读
妊娠期高血压疾病(HDCP)子痫前期是产科严重的并发症,是孕产妇和围生儿死亡的主要原因。某些胎盘因子表达的异常导致了胎盘着床异常,也使其成为疾病标志性研究的新靶点。近年来发现的DLX4基因具有高度保守的同源异型盒序列,在胚胎的分化、增殖、机体代谢以及肿瘤发生、发展过程中发挥重要作用。Fas/FasL系统表达平衡为免疫耐受提供了有力保证,一旦表达失衡,高表达Fas的胎盘滋养细胞异常凋亡,两因子的相关性可能引起HDCP的发生。
Hypertensive disorders of pregnancy (HDCP) Preeclampsia is a serious obstetric complication and is the leading cause of death in both pregnant women and perinatal children. Abnormality in the expression of certain placental factors leads to abnormal placental implantation and also makes it a new target for landmark disease research. In recent years, the DLX4 gene has a highly conserved homeobox sequence that plays an important role in embryo differentiation, proliferation, metabolism and tumorigenesis and development. Fas / FasL system balance of expression provides a powerful guarantee for immune tolerance, once the imbalance in expression of Fas-rich placental trophoblasts abnormal apoptosis, the two factors may cause the occurrence of HDCP.