缓和的对称性血清阴性滑膜炎伴凹陷性水肿综合征(ＲＳ3 ＰＥ) ,是一种异质性疾病 ,病因不清 ,现报道 1例。患者 :女性 ,5 0岁。主因双踝关节肿痛 2 0余天门诊入院 ,2 0ｄ前无明显诱因出现双踝关节呈持续性肿痛 ,活动后加重 ,不伴晨僵 ,7ｄ后双踝肿痛加重 ,无法行走 ,并出现双小 Moderate Symmetry Seronegative synovitis with pitting edema syndrome (RS3 PE), is a heterogeneous disease, the etiology is unclear, is reported in 1 case. Patients: Female, 50 years old. The main double ankle joint pain due to more than 20 days outpatient admission, no obvious incentive before 20 days showed persistent ankle joint swelling and pain, increased activity, without morning stiffness, double ankle swelling after 7d, unable to walk, and there Double small